Syble was born on June 21, 1925 in Tahoka, Texas to N.B. and Ollie Brower. She graduated from Tahoka High School. Syble married William Harry Wilkinson on May 2, 1947. He preceded her in death in 1990. She worked in production for Levi-Strauss until retirement. She was a longtime member of Calvary Baptist Church.
Survivors left to cherish her memories are her two daughters, Catherine H. Waters and her husband James of Mauldin, S.C., and Andrea E. Hickenbottom and her husband Robert of Amarillo; five grandchildren, Jamie Wilkie and her husband Greg of Woodruff, S.C., Gena Dalton and her husband Chris of Mauldin, S.C., Robby Carter and his wife Sommer of Amarillo, Angela Waggoner and her husband Loy of Amarillo and Dustin Hickenbottom of Amarillo; fourteen great-grandchildren and three great-great-grandchildren.
She was preceded in death by her parents, husband, two brothers and two sisters.